There's nothing quite like the comforting taste of Swiss Chicken Casserole fresh out of the oven. With tender chicken, a creamy sauce, and a crunchy, buttery topping, this dish is the ultimate cozy meal for busy weeknights or family gatherings.

I first discovered this recipe when looking for an easy way to use up leftover Swiss cheese. One bite, and I was hooked! Now, it's a staple in my home, especially when I need something delicious with minimal effort. If you're a fan of creamy casseroles, this one is sure to become a favorite.
Why You'll Love This Swiss Chicken Casserole
Get ready to fall in love with your new go-to comfort food. This Swiss Chicken Casserole is packed with flavor and comes together in just a few simple steps.
First, it's incredibly easy to make. With only a handful of ingredients and minimal prep work, you can have this casserole ready for the oven in under 10 minutes. Perfect for those nights when you need a stress-free dinner!
The creamy sauce keeps the chicken juicy and tender. A blend of cream of chicken soup and sour cream creates the perfect texture, coating every bite with rich, savory goodness.
Let's not forget the crispy, buttery topping. Buttery crushed crackers add the perfect crunch, balancing out the creaminess of the dish and making each forkful absolutely irresistible.
Finally, this recipe is ideal for meal prep. Make it ahead of time and pop it in the oven when you're ready, or enjoy leftovers the next day – it tastes just as amazing reheated!
Ingredients Notes

The magic of this Swiss Chicken Casserole comes from a few key ingredients that work together to create a rich, comforting dish.
Chicken – Boneless, skinless chicken breasts work best for this recipe. You can use whole pieces or cut them into bite-sized chunks for easier serving. Rotisserie chicken is also a great shortcut if you're in a hurry!
Swiss cheese – The mild, nutty flavor of Swiss cheese is what makes this casserole stand out. If you prefer a milder taste, you can use a mix of Swiss and mozzarella.
Cream of chicken soup – This creates the creamy base for the casserole. If you prefer a homemade version, you can use a mixture of chicken broth, heavy cream, and a bit of flour to thicken it.
Sour cream – This adds tanginess and helps balance out the richness of the dish. You can substitute Greek yogurt for a slightly lighter version.
Crushed buttery crackers – Ritz crackers are my go-to choice for the topping. Their buttery crunch adds the perfect contrast to the creamy filling. If you don’t have Ritz, crushed cornflakes or panko breadcrumbs work well too.
You'll also need butter to mix with the crackers, enhancing their crispiness, and a bit of garlic powder or onion powder for extra flavor.
How To Make This Swiss Chicken Casserole

Making this Swiss Chicken Casserole is as easy as layering the ingredients and letting the oven do the work!
Start by preheating your oven to 350°F (175°C). Lightly grease a 9x13-inch baking dish to prevent sticking.
Lay the chicken breasts evenly in the baking dish. If you're using pre-cooked or shredded chicken, spread it out in an even layer.
Next, layer the Swiss cheese over the chicken. Don’t be afraid to overlap the slices slightly to ensure every bite has cheesy goodness.
In a bowl, whisk together the cream of chicken soup and sour cream. For extra flavor, stir in a pinch of garlic powder or onion powder. Spread this mixture evenly over the cheese layer, covering everything completely.
For the topping, crush about 1 ½ cups of buttery crackers and mix them with melted butter. Sprinkle the buttery crumbs over the casserole, creating an even layer of crunch.
Bake for 40-45 minutes, or until the chicken is cooked through and the topping is golden brown. If using pre-cooked chicken, you may only need 25-30 minutes to heat everything through.
Once done, let the casserole sit for a few minutes before serving. This helps the sauce thicken slightly, making it even more delicious!
Storage Options
This Swiss Chicken Casserole stores beautifully, making it a great option for leftovers.
To store in the refrigerator, place leftovers in an airtight container and refrigerate for up to 3 days. Reheat individual portions in the microwave, or warm the entire dish in the oven at 325°F for about 15 minutes.
For freezing, assemble the casserole but don’t add the cracker topping yet. Wrap it tightly with plastic wrap and aluminum foil, then freeze for up to 3 months. When ready to bake, thaw overnight in the refrigerator, add the cracker topping, and bake as directed.
If you have leftover baked casserole, you can also freeze it. Just note that the cracker topping may lose some of its crunch when reheated.
Variations and Substitutions
One of the best things about this recipe is how easily it can be customized to suit your tastes!
Switch up the cheese – While Swiss cheese gives this casserole its signature flavor, you can experiment with cheddar, provolone, or even pepper jack for a bit of spice.
Use a different protein – This dish works wonderfully with turkey, ham, or even cooked ground beef. Great for using up leftovers after the holidays!
Make it gluten-free – Swap out the cream of chicken soup for a gluten-free version, and use crushed gluten-free crackers or panko for the topping.
Add vegetables – Stir in some sautéed mushrooms, spinach, or broccoli to add a bit of color and nutrition.
Lighten it up – Use Greek yogurt instead of sour cream and opt for a reduced-fat cheese to make this dish a little healthier without sacrificing flavor.
However you decide to make it, this Swiss Chicken Casserole is guaranteed to be a hit at the dinner table. Try it once, and it just might become a regular in your meal rotation!
PrintSwiss Chicken Casserole Recipe
This Swiss chicken casserole is a comforting, creamy dish made with tender chicken breasts, Swiss cheese, and a buttery stuffing topping. Perfect for busy weeknights or cozy family dinners, this easy recipe comes together in under an hour with simple ingredients.
- Prep Time: 10 minutes
- Cook Time: 40 minutes
- Total Time: 50 minutes
- Yield: 4 servings 1x
- Category: Casserole
- Method: Stovetop
- Cuisine: American
- Diet: Gluten Free
Ingredients
- 4 boneless, skinless chicken breasts
- 6 slices Swiss cheese
- 1 can (10.5 oz) cream of chicken soup
- ½ cup milk
- 1 box (6 oz) stuffing mix
- ¼ cup butter, melted
- ½ teaspoon garlic powder
- ½ teaspoon onion powder
- Salt and pepper to taste
Instructions
- Preheat oven to 350°F (175°C). Grease a 9x13-inch baking dish.
- Place chicken breasts in the baking dish and season with salt, pepper, garlic powder, and onion powder.
- Lay Swiss cheese slices over the chicken.
- In a bowl, mix cream of chicken soup with milk, then pour over the chicken and cheese.
- Sprinkle dry stuffing mix evenly over the top.
- Drizzle melted butter over the stuffing.
- Cover with foil and bake for 30 minutes.
- Remove foil and bake for another 10–15 minutes until golden brown and bubbly.
- Let rest for 5 minutes before serving.
Notes
- Use rotisserie chicken for a quicker version.
- Substitute Swiss cheese with provolone or mozzarella if desired.
- Add sautéed mushrooms or spinach for extra flavor.
Nutrition
- Serving Size: 1 serving
- Calories: 420
- Sugar: 3g
- Sodium: 900mg
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